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KMID : 0545120170270061204
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Journal of Microbiology and Biotechnology
2017 Volume.27 No. 6 p.1204 ~ p.1308
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Recovery of NK(CD56+CD3-) Cells after One Year of Tenofovir Therapy for Chronic Hepatitis B Infection
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Lee Hwan-Hee
Kang Hyo-Jeung
Cho Hyo-sun
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Abstract
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Natural killer (NK) cells have been reported to be dysfunctional in chronic hepatitis B (CHB) infection. However, the functional recovery of NK cells under antiviral therapeutic agents in CHB was not clearly understood. In this study, we investigated the phenotypic changes of NK(CD56+CD3-) cells in terms of their functional markers (CD16, NKG2A, NKG2D) during tenofovir therapy in CHB. The frequency of NK(CD56+CD3-) cells in CHB patients was significantly increased after 12 months of tenofovir therapy when compared with baseline. The expression levels of CD16+/CD56+CD3- and NKG2A+/CD56+CD3- cells were also affected by tenofovir treatment. In addition, there was a positive correlation between the proportion of NK(CD56+CD3-) cells and HBV DNA (log copies/ml) in CHB patients.
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KEYWORD
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Chronic hepatitis B, natural killer (NK) cells, tenofovir, CD16, NKG2A
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